While it is clearly established as the agent of first choice only in pneumocystis carinii infections, it is effective in many other infectious. Sulfamethoxazole trimethoprim sulfamethoxazole trimethoprim sulfamethoxazole trimethoprim audio icon audio icon other names. Feb 12, 2018 what is sulfamethoxazole and trimethoprim. Trimethoprim tmp sulfamethoxazole smx pdf version antibiotic class. Road, suite 2500, wayne, pennsylvania 19087, usa, 20. Although other combinations of sulfonamides are available with trimethoprim, tmpsmx is by far the most widely used. Trimethoprimsulfamethoxazole tmpsmx is the only proven effective treatment of cyclosporiasis. Sulfamethoxazole inhibits the synthesis of dihydrofolic acid.
Comparison of trimethoprimsulfamethoxazole, cephadroxil. Trimethoprimsulfamethoxazole tmpsmx is a fixed combination of two antimicrobial agents a diaminopyrimidine trimethoprim and a sulfonamide sulfamethoxazole purposely chosen to. Cotrimoxazole1 trimethoprimsulfamethoxazole is a broad spectrum antimicrobial which is active in vitro against a wide variety of microorganisms. The few patients who were not cured with 7 days of therapy were cured by a total of 10 days of. Dailymed sulfamethoxazole and trimethoprim ds tablet. Sulfametoxazol trimetoprima bactrim o septra mothertobaby. Trimethoprim sulfamethoxazole for the prevention of spontaneous bacterial peritonitis in cirrhosis. Bactrim, bactrim ds trimethoprimsulfamethoxazole dosing. Sulfamethoxazole and trimethoprim oral suspension is also contraindicated in patients with marked hepatic damage or with severe renal insufficiency when renal function status cannot be monitored.
Sulfamethoxazole and trimethoprim is a synthetic antibacterial combination product available in ds double strength tablets, each containing 800 mg sulfamethoxazole and 160 mg trimethoprim. This medicine will not work for colds, flu, or other virus infections. This article is within the scope of wikiproject medicine, which recommends that medicinerelated articles follow the manual of style for medicinerelated articles and that biomedical information in any article use highquality medical sources. Once daily cefixime compared with twice daily trimethoprimsulfamethoxazole for. Trimethoprim and sulfamethoxazole tablets 10 days mouse oral 45 gkg loael liver, kidney, blood, ureter, bladder mouse intraperitoneal ld50 1870mgkg mouse oral ld50 1600mgkg sulfamethoxazole version. The antimicrobial combination of trimethoprim and sulfamethoxazole is active in vitro against various grampositive and gramnegative bacteria. The infectious diseases society of america idsa recommends a 3 day treatment course for acute, uncomplicated cystitis and a 14 day treatment course for pyelonephritis in female patients. Approved drugs for hivaids or aidsrelated conditions. Sulfamethoxazole and trimethoprim is a synthetic antibacterial combination product available in 800 mg sulfamethoxazole and 160 mg trimethoprim double strength tablets and 400 mg sulfamethoxazole and 80 mg trimethoprim tablets for oral administration. Ask your doctors advice if antibiotics such as bactrim trimethoprimsulfamethoxazole or doxycycline are used.
This medication is a combination of two antibiotics. These two agents act synergistically in inhibiting folic acid synthesis. Sulfamethoxazole and trimethoprim oral suspension is contraindicated in pediatric patients less than 2 months of age. A mixture of trimethoprim tmp and sulfamethoxazole smx, also known as cotrimoxazole, is a widely used synergistic antimicrobial combination to treat a variety of bacterial infections 2. Clsi document m100s23, clinical and laboratory standards institute, 950 west valley. If you would like to participate in the project, you can choose to edit this article, or visit the project page for more information. Trimethoprimsulfamethoxazole is a fixed drug combination that combines two compounds that block folate synthesis. Both drugs reduce the ability of some bacteria to utilize folic acid for growing. Considerations when prescribing trimethoprim sulfamethoxazole. Sulfamethoxazole and trimethoprim uses, side effects. Although trimethoprimsulfamethoxazole tmpsmx has favorable pharmacokinetics and case series of using it successfully for bsi exist, 49 tmpsmx showed inferior outcomes in a randomized trial. Jan 10, 2019 sulfamethoxazole trimethoprim sulfamethoxazole trimethoprim sulfamethoxazole trimethoprim audio icon audio icon other names. Bactrim, bactrim ds, smxtmp, septra, sulfamethoprim, sulfamethoprimds, sulfatrim, tmpsmx drug.
Clinical experience with this agent now spans a decade or more in many countries. Dailymed sulfamethoxazole and trimethoprim suspension. The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s. Bactrim is a combination of two synthetic manmade antibiotics, sulfamethoxazole and trimethoprim. This article is part of wikiproject aids, an attempt to build a comprehensive, detailed, and accessible guide to aids, hiv, and related topics on wikipedia. Enteritis caused by susceptible strains of shigella flexneri and s sonnei. Sulfamethoxazole and trimethoprim may also be used for purposes not listed in this medication guide. The drug combination is synergistic as the drugs interfere with two successive steps in the formationutilization of folic acid by. Trimethoprim exerts antimicrobial activity by blocking the reduction of dihydrofolate to tetrahydrofolate, the.
Trimethoprimsulfamethoxazole revisited infectious diseases. Septra trimethoprim and sulfamethoxazole side effects. This product is available in the following dosage forms. Although trimethoprim sulfamethoxazole tmpsmx has favorable pharmacokinetics and case series of using it successfully for bsi exist, 49 tmpsmx showed inferior outcomes in a randomized trial. Can bactrim sulfamethoxazole and trimethoprim be crushed. Trimethoprimsulfamethoxazole revisited request pdf. This document should be read in conjunction with this disclaimer. Pharmacokinetics of sulfamethoxazoleand trimethoprim after oral administration trimethoprim and sulfamethoxazole are rapidly andnearly completely absorbed.
Bactrim, bactrim ds, smxtmp, septra, sulfamethoprim, sulfamethoprimds, sulfatrim, tmpsmx drug class. Pdf trimethoprimsulfamethoxazole for treatment of severe. Approved february 8, 1995 for the treatment of mild to moderate pcp in patients who are intolerant of trimethoprim sulfamethoxazole tmpsmx approved january 5, 1999 for the prevention of pcp. Trimethoprimsulfamethoxazole is the recommended agent for the prevention of firstepisode and recurrent pcp.
It disrupts the production of dihydrofolic acid while trimethoprim disrupts the production of tetrahydrofolic acid. Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway. The presence of food does not appear to delay absorption. Bactrim sulfamethoxazole and trimethoprim ds is a combination of two antibiotics used to treat urinary tract infections, acute otitis media, bronchitis, shigellosis, pneumocystis pneumonia, travelers diarrhea, methicillinresistant staphylococcus aureus, and other bacterial infections susceptible to this antibiotic. The antimicrobial combination of trimethoprim and sulfamethoxazole is active in vitro against various. Bactrim sulfamethoxazole and trimethoprim is a synthetic antibacterial combination product available in ds double strength tablets, each containing 800 mg sulfamethoxazole and 160 mg trimethoprim. The recommended dosage for prophylaxis in adults is 1 sulfamethoxazole and trimethoprim ds double strength tablet daily12. Side effects of bactrim trimethoprim and sulfamethoxazole. Trimethoprim sulfamethoxazole tmpsmx, also known as cotrimoxazole, is a combination of two antimicrobial agents that act synergistically against a wide variety of bacteria. Cotrimoxazoletrimethoprimsulfamethoxazole springerlink.
In a randomized placebo controlled trial, a dose of sulfamethoxazole 800 mg and trimethoprim 160 mg given twice daily for 7 days was 94% curative 9. Trimethoprimsulfamethoxazole tmpsmx, also known as cotrimoxazole, is a combination of two antimicrobial agents that act synergistically against a wide variety of bacteria. Sep 20, 2019 sulfamethoxazole and trimethoprim oral suspension is contraindicated in patients with a known hypersensitivity to trimethoprim or sulfonamides, in patients with a history of druginduced immune thrombocytopenia with use of trimethoprim andor sulfonamides, and in patients with documented megaloblastic anemia due to folate deficiency. This patient antibiotic leaflet is designed to provide information that is easy to understand. It is used to treat or prevent certain kinds of bacterial infections.
For children, the recommended dose is 750 mgm2day sulfamethoxazole with 150 mgm2day trimethoprim given orally in equally divided doses twice a day, on 3 consecutive days per week. Mar 25, 2020 bactrim sulfamethoxazole and trimethoprim ds is a combination of two antibiotics used to treat urinary tract infections, acute otitis media, bronchitis, shigellosis, pneumocystis pneumonia, travelers diarrhea, methicillinresistant staphylococcus aureus, and other bacterial infections susceptible to this antibiotic. Each double strength tablet contains 800 mg sulfamethoxazole and 160 mg trimethoprim plus magnesium stearate, pregelatinized starch. Mutual potentiation drives synergy between trimethoprim. It is used to treat a wide variety of bacterial infections such as middle ear, urine, respiratory, and. Trimethoprim sulfamethoxazole is an antibiotic used to treat or prevent bacterial infections. Please visit the project page for details or ask questions at wikipedia talk. Alternatively, 810 mg tmpkgday iv divided q612hr for up to 5 days. Resistance to trimethoprimsulfamethoxazole clinical. While it is clearly established as the agent of first choice only in pneumocystis carinii infections, it is effective in many other infectious diseases. Approved february 8, 1995 for the treatment of mild to moderate pcp in patients who are intolerant of trimethoprimsulfamethoxazole tmpsmx approved january 5, 1999 for the prevention of pcp. Trimethoprim sulfamethoxazole compared with vancomycin for the treatment of staphylococcus aureus infection. Trimethoprim sulfamethoxazole has been used as the firstline agent for treatment, but mutations within dihydropteroate synthase gene render potential resistance to sulfamide. Trimethoprimsulfamethoxazole tmpsmx is a combination used to treat bacterial infections, p.
Trimethoprimsulfamethoxazole has been used as the firstline agent for treatment, but mutations within dihydropteroate synthase gene render potential resistance to sulfamide. Sulfamethoxazole and trimethoprim ds information, side. Sulfamethoxazole trimethoprim uses, side effects aidsinfo. Originally developed in the 1960s, this combination has remained an important and useful antimicrobial preparation. It will not work for colds, flu, or other viral infections. Sulfamethoxazole is an antibacterial sulfonamide, a sulfa drug.
Trimethoprimsulfamethoxazole an overview sciencedirect. Find out what health conditions may be a health risk when taken with sulfamethoxazoletrimethoprim oral. Apr 28, 2010 sulfamethoxazole and trimethoprim is a synthetic antibacterial combination product available in ds double strength tablets, each containing 800 mg sulfamethoxazole and 160 mg trimethoprim. This medicine is available only with your doctors prescription. The antibacterial chemotherapeutic era, which has dominated much of medicine in the past 50 years, was really initiated by the introduction of the sulfonamides in 1932 see d omagk 1935. Sulfamethoxazole and trimethoprim sulfamethoxazole. Sulfamethoxazoletrimethoprim oral route description and. It works by eliminating the bacteria that cause many kinds of infections. Sulfamethoxazole trimethoprim in spanish tabletwise. Antibiotic trimethoprim and sulfonamide combination in a 5. After widespread and effective use of sulfonamides in a variety of infectious diseases, resistant organisms began to emerge, at first slowly, but then with frightening rapidity. Webmd provides common contraindications for sulfamethoxazoletrimethoprim oral. Sulfamethoxazole trimethoprim fda label tablet, tablet. Sulfamethoxazole and trimethoprim combination is an antibiotic.
440 1696 160 1299 1251 619 1431 1214 751 234 34 903 1043 502 718 148 1469 1144 1331 1078 981 265 488 1671 391 222 907 533 1095 1368 1162 436 1102 346 520